BOC ANHYDRIDE

BOC ANHYDRIDE - Names and Identifiers

Name	Di-tert butyl dicarbonate
Synonyms	BOC (BOC)2O (BOC)2O FLUKA BOC ANHYDRIDE RARECHEM TB OC 0001 tert-butyldicarbonate Di-tert-butyl dicarbonate Di-tert butyl dicarbonate PYROCARBONIC ACID DI-TERT-BUTYL ESTER
CAS	24424-99-5
EINECS	246-240-1
InChI	InChI=1/C10H18O5/c1-8(2,3)11-7(10)12-9(4,5)6/h1-6H3

BOC ANHYDRIDE - Physico-chemical Properties

Molecular Formula	C10H18O5
Molar Mass	218.25
Density	0.932g/cm³
Melting Point	22-24℃
Boling Point	185.342°C at 760 mmHg
Flash Point	67.065°C
Water Solubility	Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
Vapor Presure	0.7mmHg at 25°C
Refractive Index	1.419
Physical and Chemical Properties
Use	Pharmaceutical and organic synthesis intermediates, is an important application in medicine and agrochemical products synthesis of amino protective agent

BOC ANHYDRIDE - Risk and Safety

Hazard Symbols	T+ - Very toxic F+ - Highly flammable Xi - Irritant
Risk Codes	R10 - Flammable R26 - Very Toxic by inhalation R36/37/38 - Irritating to eyes, respiratory system and skin. R43 - May cause sensitization by skin contact
Safety Description	S16 - Keep away from sources of ignition. S24 - Avoid contact with skin. S37/39 - Wear suitable gloves and eye/face protection S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	2929

BOC ANHYDRIDE - Upstream Downstream Industry

Raw Materials

Tetrahydrofuran
Carbon tetrachloride
CARBON DIOXIDE
Potassium tert-butoxide
1,8-Diazabicyclo[5.4.0]undec-7-ene
N-OCTANE

Downstream Products

N-Boc-D-proline
BOC-L-Isoleucine
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE
1-Boc-4-cyanopiperidine
TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID
1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE
(S)-N-Boc-allylglycine
TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE
2-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID
1-Boc-piperazine acetate
Spermidine
TERT-BUTYL 3-(4-AMINO-2,6-DICHLOROPHENOXY)PROPYLCARBAMATE
3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID
6-BOC-HYDRAZINONICOTINIC ACID
4-BOCAMINO-NICOTINIC ACID
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
(R)-PIPERAZINE-2-CARBOXYLIC ACID
(3-HYDROXYMETHYL-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
6-(BOC-AMINO)-HEXYL BROMIDE
N-1-BOC-N-4-CBZ-2-PIPERAZINECARBOXYLIC ACID T-BUTYL ESTER
4-ALLYL-PIPERIDINE-1,4-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER
1-BOC-PIPERAZINE
TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE
1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE
(S)-(-)-1-Boc-2-pyrrolidinemethanol
TERT-BUTYL 4-FORMYL-2-METHOXYPHENYL CARB ONATE, 99
3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE
tert-Butyl N-(2-bromoethyl)carbamate
N-Boc-N,N-bis(2-chloroethyl)amine
4-CHLORO-(N-BOC)ANILINE 97
TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE
4-(BOC-AMINOMETHYL)PYRIDINE
N-BOC-piperidine-4-carboxylic acid
1-(4-PYRIDYLMETHYL)PIPERAZINE
N,N-DIMETHYL-2-PIPERAZIN-1-YL-ACETAMIDE
1-Boc-3-oxopiperazine

BOC ANHYDRIDE - Introduction

Open Data Unverified Data

Diethyl adipate (CAS 24424-99-5) is a compound with the chemical formula C10H18O5. It is a colorless and transparent liquid. Diethyl adipate is soluble in alcohols, ethers, and benzene, but insoluble in water, and it has a density of 0.932g/cm3.

Diethyl adipate is commonly used in the following areas:

1. Solvent: It is widely used as a solvent to dissolve certain compounds in chemical and laboratory applications due to its good solubility.
2. Chemical synthesis: It is used in organic synthesis reactions, for example, in the synthesis of polymers and other organic compounds.
3. Preparation of coatings and resins: In the coating industry, diethyl adipate can be used as a component in resins and coatings.

Diethyl adipate is typically synthesized by the reaction of butanol and carbon dioxide. It is relatively safe to handle, but precautions should be taken to avoid skin and eye contact, as well as inhalation of its vapors. It should be stored in a cool, dry place, away from sources of ignition and oxidizing agents.

Last Update：2024-04-09 19:43:38

BOC ANHYDRIDE - Nature

Open Data Unverified Data

storage conditions	2-8°C
morphology	Low Melting Crystalline Solid
color	White
Specific gravity	0.950
water solubility	Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water.
sensitivity	Moisture Sensitive
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
EPA chemical information	Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5)

Last Update：2024-04-09 19:43:38

BOC ANHYDRIDE - Security information

WGK Germany	3
RTECS number	HT0230000
F	4.4-10-21
auto-ignition temperature	460 °C
Hazard Note	Flammable/Irritant/Very Toxic
TSCA	Yes
HazardClass	6.1
PackingGroup	I
customs code	29209010
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Last Update：2024-04-10 22:29:15

BOC ANHYDRIDE - Uses and synthesis methods

use

1. Used to introduce tert-butoxycarbonyl protecting groups in organic synthesis.

2, di-tert-butyl dicarbonate (Boc anhydride) is used in organic synthesis to introduce tert-butoxycarbonyl protection genes, especially used in amino acid protection. It is widely used in the synthesis of medicine, protein and polypeptide synthesis, biochemical food, cosmetics and other products.

3. amino acid BOC reagent. In organic synthesis, it is used to introduce tert-butoxyl carbonyl (BOC) protective group, especially suitable for amino acid protection. Tritertylbutoxycarbonyl-protected hydrazine can be prepared in chromogenic reagents for fluorene methoxycarbonyl? esters to monitor solid-phase aldehydes. Reagents used to prepare amines protected by tert-butoxycarbonyl. Reagents for the introduction of tert-butoxycarbonyl protecting groups. Alcohols such as tert-butoxycarbonyl derivatives can be protected by Lewis acid catalysis. Aminomethylpropene is prepared by the reaction of tert-butoxycarbonylaminopropyne with formaldehyde, diisopropylamine and copper bromide?, which is a component of many bovine plasma amine oxidase inactivators.

4. Used as an intermediate in medicine and organic synthesis, it is an important amino protective agent used in the synthesis of medicine and agrochemical products

production method

Potassium tert-butoxide is dissolved in anhydrous tetrahydrofuran, and dry carbon dioxide is introduced at -5 ~-20 ℃ to generate a slurry, continue to maintain a low temperature, and add phosgene benzene solution dropwise to prepare tert-butyl tricarbonate. Dissolve it in carbon tetrachloride, add an appropriate amount of 1,4-diazabicyclo [2,2] octane, stir at 25 ℃ to completely release carbon dioxide and convert it into ditert-butyl dicarbonate.

Last Update：2024-04-09 21:00:56

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